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Combretastatin A4 Phosphate Disodium Salt

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Formula: C18H19O8P.2Na
CAS: 168555-66-6

Identification

Structural Formula
Combretastatin A4 Phosphate Disodium Salt
CAS:
168555-66-6
EINECS:
Molecular Formula:
C18H19O8P.2Na
MDL:
MFCD00943911
SMILES:
COC1=C(C=C(C=C1)/C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]
Synonym:
combretastatin a4 disodium phosphate ; ca-4p, combretastatin a-4 phosphate ; combretastatin a-4 phosphate ; fosbretabulin (disodium) ; ca4p ; combretastatin a4 disodium ; fosbretabulin disodium (ca4p) ; combretastatin a4 phosphate(ca4p) ; fosbretabulin disodium salt ; combretastatin a4 phosphate disodium


Description

Combretastatin A4 Phosphate Disodium Salt is the salt form of Combretastatin A4, a phosphorylated microtubule depolymerizing molecule which induces tumor necrosis by regression of unstable nascent tumor neo-vessels. Studies suggest that Combretastatin A4 Phosphate Disodium Salt selectively inhibits endothelial tumor cells via disrupting VE-cadherin (vascular endothelial-cadherin). In addition, Combretastatin A4 Phosphate Disodium Salt can increase the permeability of endothelial cells while inhibiting their migration and suppress capillary tube formation via disruption of VE-cadherin. Furthermore, Combretastatin A4 Phosphate Disodium Salt can change the morphology of endothelial cells by altering their tubulin cytoskeleton.


Suppliers

Autech Industry Co.,Limited
AIC553522140
H&Z Industry Co.,Ltd
HIC410016400
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI1414556580
Santa Cruz Biotechnology, Inc.
211124
Dayang Chem (Hangzhou) Co.,Ltd.
DC635525420
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Prices & Availability




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Properties for Combretastatin A4 Phosphate Disodium Salt

Molecular Weight:
440.29 g·mol−1
Melting point:
238-242 °C
Solubility:
Soluble in Methanol
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Safety & Transport Information

Storage temperature :
Refrigerator
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Alternative Distributors of [Combretastatin A4 Phosphate Disodium Salt]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ShangHai Biochempartner Co., Ltd. | Hefei Photochem Trading Co., Ltd | Jinan Great Chemical Co., Ltd. | East Chemical Industry Co., Ltd. | BOC Sciences | Wolves R&D Chemicals

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